Whole genome sequencing of drug-resistant Mycobacterium tuberculosis isolates in Victoria, Australia

T Dorji; K Horan; NL Sherry; EL Tay; M Globan; L Viberg; K Bond; JT Denholm; BP Howden; P Andersson

Journal article

Whole genome sequencing of drug-resistant Mycobacterium tuberculosis isolates in Victoria, Australia

T Dorji, K Horan, NL Sherry, EL Tay, M Globan, L Viberg, K Bond, JT Denholm, BP Howden, P Andersson

International Journal of Infectious Diseases | ELSEVIER SCI LTD | Published : 2024

DOI: 10.1016/j.ijid.2023.11.010

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Abstract

Objectives: Whole genome sequencing (WGS) can identify clusters, transmission patterns, and drug resistance mutations. This is important in low-burden settings such as Australia, as it can assist in efficient contact tracing and surveillance. Methods: We conducted a retrospective cohort study using WGS from 155 genomically defined drug-resistant Mycobacterium tuberculosis (DR-TB) isolates collected between 2018-2021 in Victoria, Australia. Bioinformatic analysis was performed to identify resistance-conferring mutations, lineages, clusters and understand how local sequences compared with international context. Results: Of the 155 sequences, 42% were identified as lineage 2 and 35% as lineage ..

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University of Melbourne Researchers

Kristy Horan Horan Author

Norelle Sherry Author

Maria Globan Author

Justin Denholm Author

Related Projects (1)

IMPROVING PREVENTION, TRACKING AND TREATMENT OF MAJOR HUMAN BACTERIAL PATHOGENS

This research fellowship will lead to a detailed understanding of the mechanisms by which bacteria become resistant to antibiotics and cause..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council, Australia (NHMRC) Practitioner Fellowship to BPH (APP1105905). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.